Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report

Adrenal disease is an uncommon manifestation of hepatitis C infection and its related treatment regimen. This is a case of subclinical hypoadrenalism, probably induced by hepatitis C infection and further exacerbated by interferon-α2β and Ribavirin therapy. The adrenal deterioration during the treat...

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Autores principales: Tran, Huy A, Song, Shuzhen, Lojewski, Robert J, Reeves, Glenn E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556317/
https://www.ncbi.nlm.nih.gov/pubmed/18801174
http://dx.doi.org/10.1186/1757-1626-1-157
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author Tran, Huy A
Song, Shuzhen
Lojewski, Robert J
Reeves, Glenn E
author_facet Tran, Huy A
Song, Shuzhen
Lojewski, Robert J
Reeves, Glenn E
author_sort Tran, Huy A
collection PubMed
description Adrenal disease is an uncommon manifestation of hepatitis C infection and its related treatment regimen. This is a case of subclinical hypoadrenalism, probably induced by hepatitis C infection and further exacerbated by interferon-α2β and Ribavirin therapy. The adrenal deterioration during the treatment course was observed closely with 24-hour salivary profiles and 250 μg adrenocorticotropin stimulation tests using parallel serum and salivary cortisol concentrations. A number of possible pathogenic mechanisms are discussed, and the controversy over its management is emphasized.
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spelling pubmed-25563172008-09-30 Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report Tran, Huy A Song, Shuzhen Lojewski, Robert J Reeves, Glenn E Cases J Case Report Adrenal disease is an uncommon manifestation of hepatitis C infection and its related treatment regimen. This is a case of subclinical hypoadrenalism, probably induced by hepatitis C infection and further exacerbated by interferon-α2β and Ribavirin therapy. The adrenal deterioration during the treatment course was observed closely with 24-hour salivary profiles and 250 μg adrenocorticotropin stimulation tests using parallel serum and salivary cortisol concentrations. A number of possible pathogenic mechanisms are discussed, and the controversy over its management is emphasized. BioMed Central 2008-09-18 /pmc/articles/PMC2556317/ /pubmed/18801174 http://dx.doi.org/10.1186/1757-1626-1-157 Text en Copyright © 2008 Tran et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tran, Huy A
Song, Shuzhen
Lojewski, Robert J
Reeves, Glenn E
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
title Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
title_full Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
title_fullStr Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
title_full_unstemmed Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
title_short Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report
title_sort exacerbation of hepatitis c induced subclinical hypoadrenalism by interferon-alpha2beta: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556317/
https://www.ncbi.nlm.nih.gov/pubmed/18801174
http://dx.doi.org/10.1186/1757-1626-1-157
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AT lojewskirobertj exacerbationofhepatitiscinducedsubclinicalhypoadrenalismbyinterferonalpha2betaacasereport
AT reevesglenne exacerbationofhepatitiscinducedsubclinicalhypoadrenalismbyinterferonalpha2betaacasereport

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