Delayed maturation of an IL-12–producing dendritic cell subset explains the early Th2 bias in neonatal immunity

Primary neonatal T cell responses comprise both T helper (Th) cell subsets, but Th1 cells express high levels of interleukin 13 receptor α1 (IL-13Rα1), which heterodimerizes with IL-4Rα. During secondary antigen challenge, Th2-produced IL-4 triggers the apoptosis of Th1 cells via IL-4Rα/IL-13Rα1, th...

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Detalles Bibliográficos
Autores principales: Lee, Hyun-Hee, Hoeman, Christine M., Hardaway, John C., Guloglu, F. Betul, Ellis, Jason S., Jain, Renu, Divekar, Rohit, Tartar, Danielle M., Haymaker, Cara L., Zaghouani, Habib
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556775/
https://www.ncbi.nlm.nih.gov/pubmed/18762566
http://dx.doi.org/10.1084/jem.20071371

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