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TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

The tuberous sclerosis complex (TSC)–mammalian target of rapamycin (mTOR) pathway is a key regulator of cellular metabolism. We used conditional deletion of Tsc1 to address how quiescence is associated with the function of hematopoietic stem cells (HSCs). We demonstrate that Tsc1 deletion in the HSC...

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Detalles Bibliográficos
Autores principales:	Chen, Chong, Liu, Yu, Liu, Runhua, Ikenoue, Tsuneo, Guan, Kun-Liang, Liu, Yang, Zheng, Pan
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556783/ https://www.ncbi.nlm.nih.gov/pubmed/18809716 http://dx.doi.org/10.1084/jem.20081297

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