Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11–17) provides evidence that in Drosophila melanogaster a signaling network controlled by t...

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Detalles Bibliográficos
Autores principales: Filippi, Beatrice Maria, Alessi, Dario R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557034/
https://www.ncbi.nlm.nih.gov/pubmed/18838550
http://dx.doi.org/10.1083/jcb.200809056
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author Filippi, Beatrice Maria
Alessi, Dario R.
author_facet Filippi, Beatrice Maria
Alessi, Dario R.
author_sort Filippi, Beatrice Maria
collection PubMed
description A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11–17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.
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spelling pubmed-25570342009-04-06 Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters Filippi, Beatrice Maria Alessi, Dario R. J Cell Biol Reviews A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11–17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities. The Rockefeller University Press 2008-10-06 /pmc/articles/PMC2557034/ /pubmed/18838550 http://dx.doi.org/10.1083/jcb.200809056 Text en © 2008 Filippi and Alessi This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Filippi, Beatrice Maria
Alessi, Dario R.
Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters
title Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters
title_full Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters
title_fullStr Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters
title_full_unstemmed Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters
title_short Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters
title_sort novel role for the lkb1 pathway in controlling monocarboxylate fuel transporters
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557034/
https://www.ncbi.nlm.nih.gov/pubmed/18838550
http://dx.doi.org/10.1083/jcb.200809056
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