Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

Here we show that blocking the adhesive function of αvβ3 integrin with soluble RGD ligands, such as osteopontin or cilengitide, promoted association of Rab-coupling protein (RCP) with α5β1 integrin and drove RCP-dependent recycling of α5β1 to the plasma membrane and its mobilization to dynamic ruffl...

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Detalles Bibliográficos
Autores principales: Caswell, Patrick T., Chan, May, Lindsay, Andrew J., McCaffrey, Mary W., Boettiger, David, Norman, Jim C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557049/
https://www.ncbi.nlm.nih.gov/pubmed/18838556
http://dx.doi.org/10.1083/jcb.200804140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557049/
https://www.ncbi.nlm.nih.gov/pubmed/18838556
http://dx.doi.org/10.1083/jcb.200804140

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