A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes

Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one...

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Detalles Bibliográficos
Autores principales: Andreeva, Antonina, Tidow, Henning
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Discovery Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562017/
https://www.ncbi.nlm.nih.gov/pubmed/18703587
http://dx.doi.org/10.1093/bioinformatics/btn431
Descripción
Sumario:Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module. Contact: tony@mrc-lmb.cam.ac.uk Supplementary information: Supplementary data are available on Bioinformatics online.

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