A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes

Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one...

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Detalles Bibliográficos
Autores principales: Andreeva, Antonina, Tidow, Henning
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Discovery Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562017/
https://www.ncbi.nlm.nih.gov/pubmed/18703587
http://dx.doi.org/10.1093/bioinformatics/btn431
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author Andreeva, Antonina
Tidow, Henning
author_facet Andreeva, Antonina
Tidow, Henning
author_sort Andreeva, Antonina
collection PubMed
description Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module. Contact: tony@mrc-lmb.cam.ac.uk Supplementary information: Supplementary data are available on Bioinformatics online.
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spelling pubmed-25620172009-02-25 A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes Andreeva, Antonina Tidow, Henning Bioinformatics Discovery Note Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module. Contact: tony@mrc-lmb.cam.ac.uk Supplementary information: Supplementary data are available on Bioinformatics online. Oxford University Press 2008-10-15 2008-08-14 /pmc/articles/PMC2562017/ /pubmed/18703587 http://dx.doi.org/10.1093/bioinformatics/btn431 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discovery Note
Andreeva, Antonina
Tidow, Henning
A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
title A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
title_full A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
title_fullStr A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
title_full_unstemmed A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
title_short A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
title_sort novel chhc zn-finger domain found in spliceosomal proteins and trna modifying enzymes
topic Discovery Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562017/
https://www.ncbi.nlm.nih.gov/pubmed/18703587
http://dx.doi.org/10.1093/bioinformatics/btn431
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