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Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors
BACKGROUND: Alpha-Synuclein (α-syn), a 140 amino acid protein associated with presynaptic membranes in brain, is a major constituent of Lewy bodies in Parkinson's disease (PD). Three missense mutations (A30P, A53T and E46K) in the α-syn gene are associated with rare autosomal dominant forms of...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562387/ https://www.ncbi.nlm.nih.gov/pubmed/18808659 http://dx.doi.org/10.1186/1471-2202-9-92 |