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Dysfunction of Nrf-2 in CF Epithelia Leads to Excess Intracellular H(2)O(2) and Inflammatory Cytokine Production

Cystic fibrosis is characterized by recurring pulmonary exacerbations that lead to the deterioration of lung function and eventual lung failure. Excessive inflammatory responses by airway epithelia have been linked to the overproduction of the inflammatory cytokine IL-6 and IL-8. The mechanism by wh...

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Detalles Bibliográficos
Autores principales:	Chen, Junnan, Kinter, Michael, Shank, Samuel, Cotton, Calvin, Kelley, Thomas J., Ziady, Assem G.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563038/ https://www.ncbi.nlm.nih.gov/pubmed/18846238 http://dx.doi.org/10.1371/journal.pone.0003367

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