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Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues

Immunocytochemical detection of disseminated tumour cells in the bone marrow of patients with primary breast cancer at surgery has been shown to be an independent prognostic factor in single institutional studies and in a large pooled analysis. However, bone marrow sampling and assessment of dissemi...

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Detalles Bibliográficos
Autores principales: Vincent-Salomon, A, Bidard, F C, Pierga, J Y
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564844/
https://www.ncbi.nlm.nih.gov/pubmed/18037661
http://dx.doi.org/10.1136/jcp.2007.046649
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author Vincent-Salomon, A
Bidard, F C
Pierga, J Y
author_facet Vincent-Salomon, A
Bidard, F C
Pierga, J Y
author_sort Vincent-Salomon, A
collection PubMed
description Immunocytochemical detection of disseminated tumour cells in the bone marrow of patients with primary breast cancer at surgery has been shown to be an independent prognostic factor in single institutional studies and in a large pooled analysis. However, bone marrow sampling and assessment of disseminated tumour cells is not a routine procedure in the clinical management of patients with breast cancer, but will certainly play a role in the near future for risk stratification and monitoring of therapeutic efficacy. Accurate identification of disseminated tumour cells in bone marrow must be based on standardised methodologies and procedures. This review describes these methodologies and the standardised morphological criteria used for disseminated tumour cell detection. The prognostic value of circulating tumour cells detection in peripheral blood is demonstrated in patients with metastatic disease but remains to be substantiated at early stage. The significance of disseminated tumour cells in bone marrow and in the blood for the prediction of response to therapy is briefly summarised. Finally, this review addresses the main biological questions raised by disseminated tumour cells, in particular understanding tumour dormancy and identifying metastatic stem cells.
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spelling pubmed-25648442008-10-24 Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues Vincent-Salomon, A Bidard, F C Pierga, J Y J Clin Pathol Reviews Immunocytochemical detection of disseminated tumour cells in the bone marrow of patients with primary breast cancer at surgery has been shown to be an independent prognostic factor in single institutional studies and in a large pooled analysis. However, bone marrow sampling and assessment of disseminated tumour cells is not a routine procedure in the clinical management of patients with breast cancer, but will certainly play a role in the near future for risk stratification and monitoring of therapeutic efficacy. Accurate identification of disseminated tumour cells in bone marrow must be based on standardised methodologies and procedures. This review describes these methodologies and the standardised morphological criteria used for disseminated tumour cell detection. The prognostic value of circulating tumour cells detection in peripheral blood is demonstrated in patients with metastatic disease but remains to be substantiated at early stage. The significance of disseminated tumour cells in bone marrow and in the blood for the prediction of response to therapy is briefly summarised. Finally, this review addresses the main biological questions raised by disseminated tumour cells, in particular understanding tumour dormancy and identifying metastatic stem cells. BMJ Publishing Group 2008-05 2007-11-23 /pmc/articles/PMC2564844/ /pubmed/18037661 http://dx.doi.org/10.1136/jcp.2007.046649 Text en © Vincent-Salomon et al 2008 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Vincent-Salomon, A
Bidard, F C
Pierga, J Y
Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
title Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
title_full Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
title_fullStr Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
title_full_unstemmed Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
title_short Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
title_sort bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564844/
https://www.ncbi.nlm.nih.gov/pubmed/18037661
http://dx.doi.org/10.1136/jcp.2007.046649
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