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Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration

BACKGROUND: Aberrations in DNA methylation patterns promote changes in gene expression patterns and are invariably associated with neoplasia. DNA methylation is carried out and maintained by several DNA methyltransferases (DNMTs) among which DNMT1 functions as a maintenance methylase while DNMT3a an...

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Detalles Bibliográficos
Autores principales:	Yaqinuddin, Ahmed, Qureshi, Sohail A, Qazi, Romena, Abbas, Farhat
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564899/ https://www.ncbi.nlm.nih.gov/pubmed/18798999 http://dx.doi.org/10.1186/1475-2867-8-13

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