Extrapulmonary small cell sarcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

BACKGROUND: Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. CASE PRESENTATION: We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed b...

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Detalles Bibliográficos
Autores principales: Hueser, Christopher N, Nguyen, Nghi C, Osman, Medhat, Havlioglu, Necat, Patel, Anjali J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564932/
https://www.ncbi.nlm.nih.gov/pubmed/18817561
http://dx.doi.org/10.1186/1477-7819-6-102
Descripción
Sumario:BACKGROUND: Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. CASE PRESENTATION: We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [(18)F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up. CONCLUSION: Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.

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