Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice

BACKGROUND: Mouse virulence assessments of certain Mycobacterium tuberculosis mutants have revealed an immunopathology defect in which high tissue CFU counts are observed but the tissue pathology and lethality are reduced. M. tuberculosis mutants which grow and persist in the mouse lungs, but have a...

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Detalles Bibliográficos
Autores principales: Abdul-Majid, Khairul-Bariah, Ly, Lan H, Converse, Paul J, Geiman, Deborah E, McMurray, David N, Bishai, William R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564956/
https://www.ncbi.nlm.nih.gov/pubmed/18798983
http://dx.doi.org/10.1186/1471-2180-8-151

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