Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection

The mechanisms underlying rejection of grafted neural tissue are still being defined. Mechanisms relevant to genetically engineered cells are of current interest. To date, attention has focused on major histocompatibility complex (MHC) antigens as targets of graft rejection. Yet even when there is n...

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Detalles Bibliográficos
Autores principales: Lampson, L. A., Lampson, M. A., Dunne, A. D.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565169/
http://dx.doi.org/10.1155/NP.1992.240
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author Lampson, L. A.
Lampson, M. A.
Dunne, A. D.
author_facet Lampson, L. A.
Lampson, M. A.
Dunne, A. D.
author_sort Lampson, L. A.
collection PubMed
description The mechanisms underlying rejection of grafted neural tissue are still being defined. Mechanisms relevant to genetically engineered cells are of current interest. To date, attention has focused on major histocompatibility complex (MHC) antigens as targets of graft rejection. Yet even when there is no MHC disparity, as when the patient's own cells are genetically altered, there is still a potential for graft rejection, directed against the novel antigens. We illustrate this in a rat model.
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spelling pubmed-25651692008-10-16 Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection Lampson, L. A. Lampson, M. A. Dunne, A. D. J Neural Transplant Plast Article The mechanisms underlying rejection of grafted neural tissue are still being defined. Mechanisms relevant to genetically engineered cells are of current interest. To date, attention has focused on major histocompatibility complex (MHC) antigens as targets of graft rejection. Yet even when there is no MHC disparity, as when the patient's own cells are genetically altered, there is still a potential for graft rejection, directed against the novel antigens. We illustrate this in a rat model. Hindawi Publishing Corporation 1992 /pmc/articles/PMC2565169/ http://dx.doi.org/10.1155/NP.1992.240 Text en Copyright © 1992 .
spellingShingle Article
Lampson, L. A.
Lampson, M. A.
Dunne, A. D.
Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
title Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
title_full Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
title_fullStr Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
title_full_unstemmed Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
title_short Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
title_sort defining the range of cellular components, including internal antigens, that can serve as targets of graft rejection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565169/
http://dx.doi.org/10.1155/NP.1992.240
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