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6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally MPTP-Treated Monkeys
Intravenous administration of (15)O-labeled water and 6-[(18)F]-L-fluorodopa were used to assess abnormal striatal activity in monkeys after long-term recovery of unilateral lesions of the dopaminergic nigro-striatal system induced by the neurotoxin MPTP. PET data were examined in relation to behavi...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565248/ https://www.ncbi.nlm.nih.gov/pubmed/7509198 http://dx.doi.org/10.1155/NP.1993.27 |
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author | Doudet, Doris J. Wyatt, Richard Jed Cannon-Spoor, Eleanor Suddath, Richard McLellan, Catherine A. Cohen, Robert M. |
author_facet | Doudet, Doris J. Wyatt, Richard Jed Cannon-Spoor, Eleanor Suddath, Richard McLellan, Catherine A. Cohen, Robert M. |
author_sort | Doudet, Doris J. |
collection | PubMed |
description | Intravenous administration of (15)O-labeled water and 6-[(18)F]-L-fluorodopa were used to assess abnormal striatal activity in monkeys after long-term recovery of unilateral lesions of the dopaminergic nigro-striatal system induced by the neurotoxin MPTP. PET data were examined in relation to behavioral and biological parameters. Cerebral blood flow and 6-[(18)F]-L-DOPA uptake were found to be significantly reduced in the lesioned striatum, compared to the unaffected side and to normal controls. There was no correlation between cerebral blood flow and any of the behavioral parameters. The uptake rate constant of (18)F-DOPA from blood to striatum and the ratios of striatum to occipital areas were highly correlated to the concentrations of homovanillic acid in the cerebrospinal fluid of the same animals but not to the rotational behavior. This MPTP-inducedmodei of striatal dopamine deficiency in primates presents similarities with idiopathic Parkinson's disease and may be used to evaluate the effects of dopaminergic lesions and transplants on brain function. |
format | Text |
id | pubmed-2565248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-25652482008-10-16 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally MPTP-Treated Monkeys Doudet, Doris J. Wyatt, Richard Jed Cannon-Spoor, Eleanor Suddath, Richard McLellan, Catherine A. Cohen, Robert M. J Neural Transplant Plast Article Intravenous administration of (15)O-labeled water and 6-[(18)F]-L-fluorodopa were used to assess abnormal striatal activity in monkeys after long-term recovery of unilateral lesions of the dopaminergic nigro-striatal system induced by the neurotoxin MPTP. PET data were examined in relation to behavioral and biological parameters. Cerebral blood flow and 6-[(18)F]-L-DOPA uptake were found to be significantly reduced in the lesioned striatum, compared to the unaffected side and to normal controls. There was no correlation between cerebral blood flow and any of the behavioral parameters. The uptake rate constant of (18)F-DOPA from blood to striatum and the ratios of striatum to occipital areas were highly correlated to the concentrations of homovanillic acid in the cerebrospinal fluid of the same animals but not to the rotational behavior. This MPTP-inducedmodei of striatal dopamine deficiency in primates presents similarities with idiopathic Parkinson's disease and may be used to evaluate the effects of dopaminergic lesions and transplants on brain function. Hindawi Publishing Corporation 1993 /pmc/articles/PMC2565248/ /pubmed/7509198 http://dx.doi.org/10.1155/NP.1993.27 Text en Copyright © 1993 . |
spellingShingle | Article Doudet, Doris J. Wyatt, Richard Jed Cannon-Spoor, Eleanor Suddath, Richard McLellan, Catherine A. Cohen, Robert M. 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally MPTP-Treated Monkeys |
title | 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally
MPTP-Treated Monkeys |
title_full | 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally
MPTP-Treated Monkeys |
title_fullStr | 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally
MPTP-Treated Monkeys |
title_full_unstemmed | 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally
MPTP-Treated Monkeys |
title_short | 6-[(18)F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally
MPTP-Treated Monkeys |
title_sort | 6-[(18)f]fluoro-l-dopa and cerebral blood flow in unilaterally
mptp-treated monkeys |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565248/ https://www.ncbi.nlm.nih.gov/pubmed/7509198 http://dx.doi.org/10.1155/NP.1993.27 |
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