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Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat

In electrophysiological terms, experimental models of durable information storage in the brain include long-term potentiation (LTP), long-term depression, and kindling. Protein synthesis correlates with these enduring processes. We propose a fourth example of long-lasting information storage in the...

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Autores principales: Montiel, Teresa, Almeida, Daniel, Arango, Iván, Calixto, Eduardo, Casasola, César, Brailowsky, Simón
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565370/
https://www.ncbi.nlm.nih.gov/pubmed/10709209
http://dx.doi.org/10.1155/NP.2000.1
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author Montiel, Teresa
Almeida, Daniel
Arango, Iván
Calixto, Eduardo
Casasola, César
Brailowsky, Simón
author_facet Montiel, Teresa
Almeida, Daniel
Arango, Iván
Calixto, Eduardo
Casasola, César
Brailowsky, Simón
author_sort Montiel, Teresa
collection PubMed
description In electrophysiological terms, experimental models of durable information storage in the brain include long-term potentiation (LTP), long-term depression, and kindling. Protein synthesis correlates with these enduring processes. We propose a fourth example of long-lasting information storage in the brain, which we call the GABA-withdrawal syndrome (GWS). In rats, withdrawal of a chronic intracortical infusion of GABA, a ubiquitous inhibitory neurotransmitter, induced epileptogenesis at the infusion site. This overt GWS lasted for days. Anisomycin, a protein synthesis inhibitor, prevented the appearance of GWS in vivo. Hippocampal and neocortical slices showed a similar post-GABA hyperexcitability in vitro and an enhanced susceptibility to LTP induction. One to four months after the epileptic behavior disappeared, systemic administration of a subconvulsant dose of pentylenetetrazol produced the reappearance of paroxysmal activity. The long-lasting effects of tonic GABA(A) receptor stimulation may be involved in long-term information storage processes at the cortical level, whereas the cessation of GABA(A) receptor stimulation may be involved in chronic pathological conditions, such as epilepsy. Furthermore, we propose that GWS may represent a common key factor in the addiction to GABAergic agents (for example, barbiturates, benzodiazepines, and ethanol). GWS represents a novel form of neurono-glial plasticity. The mechanisms of this phenomenon remain to be understood.
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spelling pubmed-25653702008-10-16 Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat Montiel, Teresa Almeida, Daniel Arango, Iván Calixto, Eduardo Casasola, César Brailowsky, Simón Neural Plast Article In electrophysiological terms, experimental models of durable information storage in the brain include long-term potentiation (LTP), long-term depression, and kindling. Protein synthesis correlates with these enduring processes. We propose a fourth example of long-lasting information storage in the brain, which we call the GABA-withdrawal syndrome (GWS). In rats, withdrawal of a chronic intracortical infusion of GABA, a ubiquitous inhibitory neurotransmitter, induced epileptogenesis at the infusion site. This overt GWS lasted for days. Anisomycin, a protein synthesis inhibitor, prevented the appearance of GWS in vivo. Hippocampal and neocortical slices showed a similar post-GABA hyperexcitability in vitro and an enhanced susceptibility to LTP induction. One to four months after the epileptic behavior disappeared, systemic administration of a subconvulsant dose of pentylenetetrazol produced the reappearance of paroxysmal activity. The long-lasting effects of tonic GABA(A) receptor stimulation may be involved in long-term information storage processes at the cortical level, whereas the cessation of GABA(A) receptor stimulation may be involved in chronic pathological conditions, such as epilepsy. Furthermore, we propose that GWS may represent a common key factor in the addiction to GABAergic agents (for example, barbiturates, benzodiazepines, and ethanol). GWS represents a novel form of neurono-glial plasticity. The mechanisms of this phenomenon remain to be understood. Hindawi Publishing Corporation 2000 /pmc/articles/PMC2565370/ /pubmed/10709209 http://dx.doi.org/10.1155/NP.2000.1 Text en Copyright © 2000 .
spellingShingle Article
Montiel, Teresa
Almeida, Daniel
Arango, Iván
Calixto, Eduardo
Casasola, César
Brailowsky, Simón
Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat
title Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat
title_full Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat
title_fullStr Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat
title_full_unstemmed Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat
title_short Long-Lasting Effects of GABA Infusion Into the Cerebral Cortex of the Rat
title_sort long-lasting effects of gaba infusion into the cerebral cortex of the rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565370/
https://www.ncbi.nlm.nih.gov/pubmed/10709209
http://dx.doi.org/10.1155/NP.2000.1
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