GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory

Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to ax...

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Detalles Bibliográficos
Autores principales: Majchrzak, M., Di Scala, G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565374/
https://www.ncbi.nlm.nih.gov/pubmed/10709211
http://dx.doi.org/10.1155/NP.2000.19
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author Majchrzak, M.
Di Scala, G.
author_facet Majchrzak, M.
Di Scala, G.
author_sort Majchrzak, M.
collection PubMed
description Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation.
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spelling pubmed-25653742008-10-16 GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory Majchrzak, M. Di Scala, G. Neural Plast Article Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation. Hindawi Publishing Corporation 2000 /pmc/articles/PMC2565374/ /pubmed/10709211 http://dx.doi.org/10.1155/NP.2000.19 Text en Copyright © 2000 .
spellingShingle Article
Majchrzak, M.
Di Scala, G.
GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
title GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
title_full GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
title_fullStr GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
title_full_unstemmed GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
title_short GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
title_sort gaba and muscimol as reversible inactivation tools in learning and memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565374/
https://www.ncbi.nlm.nih.gov/pubmed/10709211
http://dx.doi.org/10.1155/NP.2000.19
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