Long-Term Recording of LTP in Cultured Hippocampal Slices

Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was com...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimono, Ken, Baudry, Michel, Ho, Lam, Taketani, Makoto, Lynch, Gary
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565406/
https://www.ncbi.nlm.nih.gov/pubmed/12959154
http://dx.doi.org/10.1155/NP.2002.249
_version_ 1782159902077091840
author Shimono, Ken
Baudry, Michel
Ho, Lam
Taketani, Makoto
Lynch, Gary
author_facet Shimono, Ken
Baudry, Michel
Ho, Lam
Taketani, Makoto
Lynch, Gary
author_sort Shimono, Ken
collection PubMed
description Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization.
format Text
id pubmed-2565406
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-25654062008-10-16 Long-Term Recording of LTP in Cultured Hippocampal Slices Shimono, Ken Baudry, Michel Ho, Lam Taketani, Makoto Lynch, Gary Neural Plast Article Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2565406/ /pubmed/12959154 http://dx.doi.org/10.1155/NP.2002.249 Text en Copyright © 2002 .
spellingShingle Article
Shimono, Ken
Baudry, Michel
Ho, Lam
Taketani, Makoto
Lynch, Gary
Long-Term Recording of LTP in Cultured Hippocampal Slices
title Long-Term Recording of LTP in Cultured Hippocampal Slices
title_full Long-Term Recording of LTP in Cultured Hippocampal Slices
title_fullStr Long-Term Recording of LTP in Cultured Hippocampal Slices
title_full_unstemmed Long-Term Recording of LTP in Cultured Hippocampal Slices
title_short Long-Term Recording of LTP in Cultured Hippocampal Slices
title_sort long-term recording of ltp in cultured hippocampal slices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565406/
https://www.ncbi.nlm.nih.gov/pubmed/12959154
http://dx.doi.org/10.1155/NP.2002.249
work_keys_str_mv AT shimonoken longtermrecordingofltpinculturedhippocampalslices
AT baudrymichel longtermrecordingofltpinculturedhippocampalslices
AT holam longtermrecordingofltpinculturedhippocampalslices
AT taketanimakoto longtermrecordingofltpinculturedhippocampalslices
AT lynchgary longtermrecordingofltpinculturedhippocampalslices

Ejemplares similares