Cargando…

Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes

Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines....

Descripción completa

Detalles Bibliográficos
Autores principales: Savić, Miroslav M., Obradović, Dragan I., Ugrešić, Nenad D., Bokonjić, Dubravko R.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565469/
https://www.ncbi.nlm.nih.gov/pubmed/16444900
http://dx.doi.org/10.1155/NP.2005.289
_version_ 1782159916860964864
author Savić, Miroslav M.
Obradović, Dragan I.
Ugrešić, Nenad D.
Bokonjić, Dubravko R.
author_facet Savić, Miroslav M.
Obradović, Dragan I.
Ugrešić, Nenad D.
Bokonjić, Dubravko R.
author_sort Savić, Miroslav M.
collection PubMed
description Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA(A) receptors containing the α(1) and α(1) subunits, whereas the effects on procedural memory can be mainly mediated by the α(1) subunit. The pervading involvement of the α(1) subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA(A) receptors. On the other hand, the role of α(5) subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.
format Text
id pubmed-2565469
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-25654692008-10-16 Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes Savić, Miroslav M. Obradović, Dragan I. Ugrešić, Nenad D. Bokonjić, Dubravko R. Neural Plast Article Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA(A) receptors containing the α(1) and α(1) subunits, whereas the effects on procedural memory can be mainly mediated by the α(1) subunit. The pervading involvement of the α(1) subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA(A) receptors. On the other hand, the role of α(5) subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states. Hindawi Publishing Corporation 2005 /pmc/articles/PMC2565469/ /pubmed/16444900 http://dx.doi.org/10.1155/NP.2005.289 Text en Copyright © 2005 .
spellingShingle Article
Savić, Miroslav M.
Obradović, Dragan I.
Ugrešić, Nenad D.
Bokonjić, Dubravko R.
Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
title Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
title_full Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
title_fullStr Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
title_full_unstemmed Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
title_short Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
title_sort memory effects of benzodiazepines: memory stages and types versus binding-site subtypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565469/
https://www.ncbi.nlm.nih.gov/pubmed/16444900
http://dx.doi.org/10.1155/NP.2005.289
work_keys_str_mv AT savicmiroslavm memoryeffectsofbenzodiazepinesmemorystagesandtypesversusbindingsitesubtypes
AT obradovicdragani memoryeffectsofbenzodiazepinesmemorystagesandtypesversusbindingsitesubtypes
AT ugresicnenadd memoryeffectsofbenzodiazepinesmemorystagesandtypesversusbindingsitesubtypes
AT bokonjicdubravkor memoryeffectsofbenzodiazepinesmemorystagesandtypesversusbindingsitesubtypes