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A Ligand Peptide Motif Selected from a Cancer Patient Is a Receptor-Interacting Site within Human Interleukin-11

Interleukin-11 (IL-11) is a pleiotropic cytokine approved by the FDA against chemotherapy-induced thrombocytopenia. From a combinatorial selection in a cancer patient, we isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes,...

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Detalles Bibliográficos
Autores principales:	Cardó-Vila, Marina, Zurita, Amado J., Giordano, Ricardo J., Sun, Jessica, Rangel, Roberto, Guzman-Rojas, Liliana, Anobom, Cristiane D., Valente, Ana P., Almeida, Fábio C. L., Lahdenranta, Johanna, Kolonin, Mikhail G., Arap, Wadih, Pasqualini, Renata
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565473/ https://www.ncbi.nlm.nih.gov/pubmed/18941632 http://dx.doi.org/10.1371/journal.pone.0003452

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