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Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men

Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged ⩾40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk facto...

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Detalles Bibliográficos
Autores principales: Jafar, T H, Qadri, Z, Chaturvedi, N
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565583/
https://www.ncbi.nlm.nih.gov/pubmed/17646192
http://dx.doi.org/10.1136/hrt.2007.120774
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author Jafar, T H
Qadri, Z
Chaturvedi, N
author_facet Jafar, T H
Qadri, Z
Chaturvedi, N
author_sort Jafar, T H
collection PubMed
description Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged ⩾40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. Definite CAD (history and Q waves on ECG) was more prevalent in men than in women (6.1% vs 4.0%; p = 0.009). In contrast, ischaemic and major ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%, and 21.0% vs 10.5%; p<0.001 for each, respectively). All measures of CAD were strongly predicted by the metabolic syndrome, but that failed to account for the greater prevalence of ECG abnormalities in women than in men. The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men. Trial registration number: NCT00327574
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spelling pubmed-25655832008-10-24 Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men Jafar, T H Qadri, Z Chaturvedi, N Heart Global Burden of Cardiovascular Disease Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged ⩾40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. Definite CAD (history and Q waves on ECG) was more prevalent in men than in women (6.1% vs 4.0%; p = 0.009). In contrast, ischaemic and major ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%, and 21.0% vs 10.5%; p<0.001 for each, respectively). All measures of CAD were strongly predicted by the metabolic syndrome, but that failed to account for the greater prevalence of ECG abnormalities in women than in men. The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men. Trial registration number: NCT00327574 BMJ Publishing Group 2008-04 2007-07-23 /pmc/articles/PMC2565583/ /pubmed/17646192 http://dx.doi.org/10.1136/hrt.2007.120774 Text en © Jafar et al 2008 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Global Burden of Cardiovascular Disease
Jafar, T H
Qadri, Z
Chaturvedi, N
Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
title Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
title_full Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
title_fullStr Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
title_full_unstemmed Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
title_short Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
title_sort coronary artery disease epidemic in pakistan: more electrocardiographic evidence of ischaemia in women than in men
topic Global Burden of Cardiovascular Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565583/
https://www.ncbi.nlm.nih.gov/pubmed/17646192
http://dx.doi.org/10.1136/hrt.2007.120774
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