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Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells

BACKGROUND: β-catenin is a key mediator of the canonical Wnt pathway as it associates with members of the T-cell factor (TCF) family at Wnt-responsive promoters to drive the transcription of Wnt target genes. Recently, we showed that Rac1 GTPase synergizes with β-catenin to increase the activity of...

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Detalles Bibliográficos
Autores principales:	Buongiorno, Pinella, Pethe, Vaijayanti V, Charames, George S, Esufali, Susmita, Bapat, Bharati
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565678/ https://www.ncbi.nlm.nih.gov/pubmed/18826597 http://dx.doi.org/10.1186/1476-4598-7-73

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