Cargando…

Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma

PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)−308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a...

Descripción completa

Detalles Bibliográficos
Autores principales: Tekeli, Oya, Turacli, M. Erol, Egin, Yonca, Akar, Nejat, Elhan, Atilla Halil
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565691/
https://www.ncbi.nlm.nih.gov/pubmed/18852869
_version_ 1782159932555001856
author Tekeli, Oya
Turacli, M. Erol
Egin, Yonca
Akar, Nejat
Elhan, Atilla Halil
author_facet Tekeli, Oya
Turacli, M. Erol
Egin, Yonca
Akar, Nejat
Elhan, Atilla Halil
author_sort Tekeli, Oya
collection PubMed
description PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)−308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-α−308 was genotyped by polymerase chain reaction and restriction endonuclease analysis. RESULTS: We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR=2.88, 95% CI 1.15–7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p=0.023). CONCLUSIONS: Our results suggest that TNF-α−308 G/A genotype is not associated with PEX glaucoma. The −308G/A variant may be a possible protective factor against PEX.
format Text
id pubmed-2565691
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Molecular Vision
record_format MEDLINE/PubMed
spelling pubmed-25656912008-10-12 Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma Tekeli, Oya Turacli, M. Erol Egin, Yonca Akar, Nejat Elhan, Atilla Halil Mol Vis Research Article PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)−308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-α−308 was genotyped by polymerase chain reaction and restriction endonuclease analysis. RESULTS: We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR=2.88, 95% CI 1.15–7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p=0.023). CONCLUSIONS: Our results suggest that TNF-α−308 G/A genotype is not associated with PEX glaucoma. The −308G/A variant may be a possible protective factor against PEX. Molecular Vision 2008-09-30 /pmc/articles/PMC2565691/ /pubmed/18852869 Text en http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tekeli, Oya
Turacli, M. Erol
Egin, Yonca
Akar, Nejat
Elhan, Atilla Halil
Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
title Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
title_full Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
title_fullStr Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
title_full_unstemmed Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
title_short Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
title_sort tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565691/
https://www.ncbi.nlm.nih.gov/pubmed/18852869
work_keys_str_mv AT tekelioya tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma
AT turaclimerol tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma
AT eginyonca tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma
AT akarnejat tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma
AT elhanatillahalil tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma