Cargando…
Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma
PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)−308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Molecular Vision
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565691/ https://www.ncbi.nlm.nih.gov/pubmed/18852869 |
_version_ | 1782159932555001856 |
---|---|
author | Tekeli, Oya Turacli, M. Erol Egin, Yonca Akar, Nejat Elhan, Atilla Halil |
author_facet | Tekeli, Oya Turacli, M. Erol Egin, Yonca Akar, Nejat Elhan, Atilla Halil |
author_sort | Tekeli, Oya |
collection | PubMed |
description | PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)−308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-α−308 was genotyped by polymerase chain reaction and restriction endonuclease analysis. RESULTS: We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR=2.88, 95% CI 1.15–7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p=0.023). CONCLUSIONS: Our results suggest that TNF-α−308 G/A genotype is not associated with PEX glaucoma. The −308G/A variant may be a possible protective factor against PEX. |
format | Text |
id | pubmed-2565691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Molecular Vision |
record_format | MEDLINE/PubMed |
spelling | pubmed-25656912008-10-12 Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma Tekeli, Oya Turacli, M. Erol Egin, Yonca Akar, Nejat Elhan, Atilla Halil Mol Vis Research Article PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)−308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-α−308 was genotyped by polymerase chain reaction and restriction endonuclease analysis. RESULTS: We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR=2.88, 95% CI 1.15–7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p=0.023). CONCLUSIONS: Our results suggest that TNF-α−308 G/A genotype is not associated with PEX glaucoma. The −308G/A variant may be a possible protective factor against PEX. Molecular Vision 2008-09-30 /pmc/articles/PMC2565691/ /pubmed/18852869 Text en http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tekeli, Oya Turacli, M. Erol Egin, Yonca Akar, Nejat Elhan, Atilla Halil Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
title | Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
title_full | Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
title_fullStr | Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
title_full_unstemmed | Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
title_short | Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
title_sort | tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565691/ https://www.ncbi.nlm.nih.gov/pubmed/18852869 |
work_keys_str_mv | AT tekelioya tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma AT turaclimerol tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma AT eginyonca tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma AT akarnejat tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma AT elhanatillahalil tumornecrosisfactoralpha308genepolymorphismandpseudoexfoliationglaucoma |