Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α (WSX-1)

OBJECTIVE: In the present work, we investigate the role of interleukin (IL)27/IL27 receptor α (Rα) (WSX-1) in the development of autoimmune disorders in the MRL/lpr mouse, which is considered as an experimental model of systemic lupus erythaematosus (SLE) in humans. METHODS: We generated two strains...

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Detalles Bibliográficos
Autores principales: Sugiyama, N, Nakashima, H, Yoshimura, T, Sadanaga, A, Shimizu, S, Masutani, K, Igawa, T, Akahoshi, M, Miyake, K, Takeda, A, Yoshimura, A, Hamano, S, Yoshida, H
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2008
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566534/
https://www.ncbi.nlm.nih.gov/pubmed/18094002
http://dx.doi.org/10.1136/ard.2007.077537

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