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The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation
Metnase is a human SET and transposase domain protein that methylates histone H3 and promotes DNA double-strand break repair. We now show that Metnase physically interacts and co-localizes with Topoisomerase IIα (Topo IIα), the key chromosome decatenating enzyme. Metnase promotes progression through...
Autores principales: | Williamson, Elizabeth A., Rasila, Kanwaldeep Kaur, Corwin, Lori Kwan, Wray, Justin, Beck, Brian D., Severns, Virginia, Mobarak, Charlotte, Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566874/ https://www.ncbi.nlm.nih.gov/pubmed/18790802 http://dx.doi.org/10.1093/nar/gkn560 |
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