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Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF

The repair of DNA double-strand breaks by nonhomologous end-joining (NHEJ) is essential for maintenance of genomic integrity and cell viability. Central to the molecular mechanism of NHEJ is DNA ligase IV/XRCC4/XLF complex, which rejoins the DNA. During adenovirus (Ad5) infection, ligase IV is targe...

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Detalles Bibliográficos
Autores principales:	Jayaram, Sumithra, Ketner, Gary, Adachi, Noritaka, Hanakahi, Les A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566893/ https://www.ncbi.nlm.nih.gov/pubmed/18782835 http://dx.doi.org/10.1093/nar/gkn552

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