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Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania

BACKGROUND: Tuberculosis is the commonest opportunistic infection and the number one cause of death in HIV/AIDS patients in developing countries. To address the extent of the tuberculosis HIV coinfection in rural Tanzania we conducted a cross sectional study including HIV/AIDS patients attending car...

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Autores principales: Ngowi, Bernard J, Mfinanga, Sayoki G, Bruun, Johan N, Morkve, Odd
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566981/
https://www.ncbi.nlm.nih.gov/pubmed/18826574
http://dx.doi.org/10.1186/1471-2458-8-341
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author Ngowi, Bernard J
Mfinanga, Sayoki G
Bruun, Johan N
Morkve, Odd
author_facet Ngowi, Bernard J
Mfinanga, Sayoki G
Bruun, Johan N
Morkve, Odd
author_sort Ngowi, Bernard J
collection PubMed
description BACKGROUND: Tuberculosis is the commonest opportunistic infection and the number one cause of death in HIV/AIDS patients in developing countries. To address the extent of the tuberculosis HIV coinfection in rural Tanzania we conducted a cross sectional study including HIV/AIDS patients attending care and treatment clinic from September 2006 to March 2007. METHODS: Sputum samples were collected for microscopy, culture and drug susceptibility testing. Chest X-ray was done for those patients who consented. Blood samples were collected for CD4+ T cells count. RESULTS: The prevalence of tuberculosis was 20/233 (8.5%). Twenty (8.5%) sputum samples were culture positive. Eight of the culture positive samples (40%) were smear positive. Fifteen (75%) of these patients neither had clinical symptoms nor chest X-ray findings suggestive of tuberculosis. Nineteen isolates (95%) were susceptible to rifampicin, isoniazid, streptomycin and ethambutol (the first line tuberculosis drugs). One isolate (5%) from HIV/tuberculosis coinfected patients was resistant to isoniazid. No cases of multi- drug resistant tuberculosis were identified. CONCLUSION: We found high prevalence of tuberculosis disease in this setting. Chest radiograph suggestive of tuberculosis and clinical symptoms of fever and cough were uncommon findings in HIV/tuberculosis coinfected patients. Tuberculosis can occur at any stage of CD4+T cells depletion.
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spelling pubmed-25669812008-10-14 Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania Ngowi, Bernard J Mfinanga, Sayoki G Bruun, Johan N Morkve, Odd BMC Public Health Research Article BACKGROUND: Tuberculosis is the commonest opportunistic infection and the number one cause of death in HIV/AIDS patients in developing countries. To address the extent of the tuberculosis HIV coinfection in rural Tanzania we conducted a cross sectional study including HIV/AIDS patients attending care and treatment clinic from September 2006 to March 2007. METHODS: Sputum samples were collected for microscopy, culture and drug susceptibility testing. Chest X-ray was done for those patients who consented. Blood samples were collected for CD4+ T cells count. RESULTS: The prevalence of tuberculosis was 20/233 (8.5%). Twenty (8.5%) sputum samples were culture positive. Eight of the culture positive samples (40%) were smear positive. Fifteen (75%) of these patients neither had clinical symptoms nor chest X-ray findings suggestive of tuberculosis. Nineteen isolates (95%) were susceptible to rifampicin, isoniazid, streptomycin and ethambutol (the first line tuberculosis drugs). One isolate (5%) from HIV/tuberculosis coinfected patients was resistant to isoniazid. No cases of multi- drug resistant tuberculosis were identified. CONCLUSION: We found high prevalence of tuberculosis disease in this setting. Chest radiograph suggestive of tuberculosis and clinical symptoms of fever and cough were uncommon findings in HIV/tuberculosis coinfected patients. Tuberculosis can occur at any stage of CD4+T cells depletion. BioMed Central 2008-09-30 /pmc/articles/PMC2566981/ /pubmed/18826574 http://dx.doi.org/10.1186/1471-2458-8-341 Text en Copyright © 2008 Ngowi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ngowi, Bernard J
Mfinanga, Sayoki G
Bruun, Johan N
Morkve, Odd
Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania
title Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania
title_full Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania
title_fullStr Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania
title_full_unstemmed Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania
title_short Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania
title_sort pulmonary tuberculosis among people living with hiv/aids attending care and treatment in rural northern tanzania
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566981/
https://www.ncbi.nlm.nih.gov/pubmed/18826574
http://dx.doi.org/10.1186/1471-2458-8-341
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