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TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells

BACKGROUND: AKT signaling promotes cell growth, proliferation and survival and is hyperactivated in many cancers. TOR complex 2 (TORC2) activates AKT by phosphorylating it on the 'hydrophobic motif' site. Hydrophobic motif site phosphorylation is needed only for a subset of AKT functions....

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Detalles Bibliográficos
Autores principales:	Hietakangas, Ville, Cohen, Stephen M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566983/ https://www.ncbi.nlm.nih.gov/pubmed/18831768 http://dx.doi.org/10.1186/1471-2407-8-282

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