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‘Self-Protection’ of Individual CD4(+) T Cells against R5 HIV-1 Infection by the Synthesis of Anti-Viral CCR5 Ligands
It is well established that paracrine secretion of anti-viral CCR5 ligands by CD8(+) and CD4(+) T cells can block the infection of activated CD4(+) T cells by R5 and dual-tropic isolates of HIV-1. By contrast, because CD4(+) T cells can be infected by HIV-1 and at least some subsets secrete anti-vir...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567041/ https://www.ncbi.nlm.nih.gov/pubmed/18941536 http://dx.doi.org/10.1371/journal.pone.0003481 |
Sumario: | It is well established that paracrine secretion of anti-viral CCR5 ligands by CD8(+) and CD4(+) T cells can block the infection of activated CD4(+) T cells by R5 and dual-tropic isolates of HIV-1. By contrast, because CD4(+) T cells can be infected by HIV-1 and at least some subsets secrete anti-viral CCR5 ligands, it is possible that these ligands protect against HIV-1 via autocrine as well as paracrine pathways. Here we use a model primary CD4(+) T cell response in vitro to show that individual CD4(+) T cells that secrete anti-viral CCR5 ligands are ‘self-protected’ against infection with R5 but not X4 strains of HIV-1. This protection is selective for CD4(+) T cells that secrete anti-viral CCR5 ligands in that activated CD4(+) T cells in the same cultures remain infectable with R5 HIV-1. These data are most consistent with an autocrine pathway of protection in this system and indicate a previously unappreciated selective pressure on the emergence of viral variants and CD4(+) T cell phenotypes during HIV-1 infection. |
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