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Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR
Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity of the protein kinase mammalian target of rapamycin (mTOR), an...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567422/ https://www.ncbi.nlm.nih.gov/pubmed/18321872 http://dx.doi.org/10.1093/cercor/bhn026 |
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author | Schicknick, Horst Schott, Björn H. Budinger, Eike Smalla, Karl-Heinz Riedel, Anett Seidenbecher, Constanze I. Scheich, Henning Gundelfinger, Eckart D. Tischmeyer, Wolfgang |
author_facet | Schicknick, Horst Schott, Björn H. Budinger, Eike Smalla, Karl-Heinz Riedel, Anett Seidenbecher, Constanze I. Scheich, Henning Gundelfinger, Eckart D. Tischmeyer, Wolfgang |
author_sort | Schicknick, Horst |
collection | PubMed |
description | Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity of the protein kinase mammalian target of rapamycin (mTOR), and protein synthesis. This led to the hypothesis that the dopaminergic system might modulate memory formation via regulation of mTOR, which is implicated in translational control. Here, we report that the D1/D5 dopamine receptor agonist SKF-38393 substantially improved gerbils’ FM discrimination learning when administered systemically or locally into the auditory cortex shortly before, shortly after, or 1 day before conditioning. Although acquisition performance during initial training was normal, the discrimination of FMs was enhanced during retraining performed hours or days after agonist injection compared with vehicle-injected controls. The D1/D5 receptor antagonist SCH-23390, the mTOR inhibitor rapamycin, and the protein synthesis blocker anisomycin suppressed this effect. By immunohistochemistry, D1 dopamine receptors were identified in the gerbil auditory cortex predominantly in the infragranular layers. Together, these findings suggest that in the gerbil auditory cortex dopaminergic inputs regulate mTOR-mediated, protein synthesis-dependent mechanisms, thus controlling for hours or days the consolidation of memory required for the discrimination of complex auditory stimuli. |
format | Text |
id | pubmed-2567422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25674222009-02-25 Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR Schicknick, Horst Schott, Björn H. Budinger, Eike Smalla, Karl-Heinz Riedel, Anett Seidenbecher, Constanze I. Scheich, Henning Gundelfinger, Eckart D. Tischmeyer, Wolfgang Cereb Cortex Articles Previous studies in the auditory cortex of Mongolian gerbils on discrimination learning of the direction of frequency-modulated tones (FMs) revealed that long-term memory formation involves activation of the dopaminergic system, activity of the protein kinase mammalian target of rapamycin (mTOR), and protein synthesis. This led to the hypothesis that the dopaminergic system might modulate memory formation via regulation of mTOR, which is implicated in translational control. Here, we report that the D1/D5 dopamine receptor agonist SKF-38393 substantially improved gerbils’ FM discrimination learning when administered systemically or locally into the auditory cortex shortly before, shortly after, or 1 day before conditioning. Although acquisition performance during initial training was normal, the discrimination of FMs was enhanced during retraining performed hours or days after agonist injection compared with vehicle-injected controls. The D1/D5 receptor antagonist SCH-23390, the mTOR inhibitor rapamycin, and the protein synthesis blocker anisomycin suppressed this effect. By immunohistochemistry, D1 dopamine receptors were identified in the gerbil auditory cortex predominantly in the infragranular layers. Together, these findings suggest that in the gerbil auditory cortex dopaminergic inputs regulate mTOR-mediated, protein synthesis-dependent mechanisms, thus controlling for hours or days the consolidation of memory required for the discrimination of complex auditory stimuli. Oxford University Press 2008-11 2008-03-04 /pmc/articles/PMC2567422/ /pubmed/18321872 http://dx.doi.org/10.1093/cercor/bhn026 Text en © 2008 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Schicknick, Horst Schott, Björn H. Budinger, Eike Smalla, Karl-Heinz Riedel, Anett Seidenbecher, Constanze I. Scheich, Henning Gundelfinger, Eckart D. Tischmeyer, Wolfgang Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR |
title | Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR |
title_full | Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR |
title_fullStr | Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR |
title_full_unstemmed | Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR |
title_short | Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR |
title_sort | dopaminergic modulation of auditory cortex-dependent memory consolidation through mtor |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567422/ https://www.ncbi.nlm.nih.gov/pubmed/18321872 http://dx.doi.org/10.1093/cercor/bhn026 |
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