Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we...

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Detalles Bibliográficos
Autores principales: Ku, Manching, Koche, Richard P., Rheinbay, Esther, Mendenhall, Eric M., Endoh, Mitsuhiro, Mikkelsen, Tarjei S., Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S., Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M., Cowan, Chad A., Lander, Eric S., Koseki, Haruhiko, Bernstein, Bradley E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567431/
https://www.ncbi.nlm.nih.gov/pubmed/18974828
http://dx.doi.org/10.1371/journal.pgen.1000242

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