A PP1-binding motif present in BRCA1 plays a role in its DNA repair function

Protein phosphatase 1α (PP1α) regulates phosphorylation of BRCA1, which contains a PP1-binding motif (898)KVTF(901). Mutation of this motif greatly reduces the interaction between BRCA1 and PP1α. Here we show that mutation of the PP1-binding motif abolishes the ability of BRCA1 to enhance survival o...

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Detalles Bibliográficos
Autores principales: Yu, Young-Mi, Pace, Serena M., Allen, Susan R., Deng, Chu-Xia, Hsu, Lih-Ching
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2008
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567813/
https://www.ncbi.nlm.nih.gov/pubmed/18953404

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