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Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis
BACKGROUND: Female endoparasitic ichneumonid wasps inject virus-like particles into their caterpillar hosts to suppress immunity. These particles are classified as ichnovirus virions and resemble ascovirus virions, which are also transmitted by parasitic wasps and attack caterpillars. Ascoviruses re...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567993/ https://www.ncbi.nlm.nih.gov/pubmed/18801176 http://dx.doi.org/10.1186/1471-2148-8-253 |
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author | Bigot, Yves Samain, Sylvie Augé-Gouillou, Corinne Federici, Brian A |
author_facet | Bigot, Yves Samain, Sylvie Augé-Gouillou, Corinne Federici, Brian A |
author_sort | Bigot, Yves |
collection | PubMed |
description | BACKGROUND: Female endoparasitic ichneumonid wasps inject virus-like particles into their caterpillar hosts to suppress immunity. These particles are classified as ichnovirus virions and resemble ascovirus virions, which are also transmitted by parasitic wasps and attack caterpillars. Ascoviruses replicate DNA and produce virions. Polydnavirus DNA consists of wasp DNA replicated by the wasp from its genome, which also directs particle synthesis. Structural similarities between ascovirus and ichnovirus particles and the biology of their transmission suggest that ichnoviruses evolved from ascoviruses, although molecular evidence for this hypothesis is lacking. RESULTS: Here we show that a family of unique pox-D5 NTPase proteins in the Glypta fumiferanae ichnovirus are related to three Diadromus pulchellus ascovirus proteins encoded by ORFs 90, 91 and 93. A new alignment technique also shows that two proteins from a related ichnovirus are orthologs of other ascovirus virion proteins. CONCLUSION: Our results provide molecular evidence supporting the origin of ichnoviruses from ascoviruses by lateral transfer of ascoviral genes into ichneumonid wasp genomes, perhaps the first example of symbiogenesis between large DNA viruses and eukaryotic organisms. We also discuss the limits of this evidence through complementary studies, which revealed that passive lateral transfer of viral genes among polydnaviral, bacterial, and wasp genomes may have occurred repeatedly through an intimate coupling of both recombination and replication of viral genomes during evolution. The impact of passive lateral transfers on evolutionary relationships between polydnaviruses and viruses with large double-stranded genomes is considered in the context of the theory of symbiogenesis. |
format | Text |
id | pubmed-2567993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25679932008-10-16 Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis Bigot, Yves Samain, Sylvie Augé-Gouillou, Corinne Federici, Brian A BMC Evol Biol Research Article BACKGROUND: Female endoparasitic ichneumonid wasps inject virus-like particles into their caterpillar hosts to suppress immunity. These particles are classified as ichnovirus virions and resemble ascovirus virions, which are also transmitted by parasitic wasps and attack caterpillars. Ascoviruses replicate DNA and produce virions. Polydnavirus DNA consists of wasp DNA replicated by the wasp from its genome, which also directs particle synthesis. Structural similarities between ascovirus and ichnovirus particles and the biology of their transmission suggest that ichnoviruses evolved from ascoviruses, although molecular evidence for this hypothesis is lacking. RESULTS: Here we show that a family of unique pox-D5 NTPase proteins in the Glypta fumiferanae ichnovirus are related to three Diadromus pulchellus ascovirus proteins encoded by ORFs 90, 91 and 93. A new alignment technique also shows that two proteins from a related ichnovirus are orthologs of other ascovirus virion proteins. CONCLUSION: Our results provide molecular evidence supporting the origin of ichnoviruses from ascoviruses by lateral transfer of ascoviral genes into ichneumonid wasp genomes, perhaps the first example of symbiogenesis between large DNA viruses and eukaryotic organisms. We also discuss the limits of this evidence through complementary studies, which revealed that passive lateral transfer of viral genes among polydnaviral, bacterial, and wasp genomes may have occurred repeatedly through an intimate coupling of both recombination and replication of viral genomes during evolution. The impact of passive lateral transfers on evolutionary relationships between polydnaviruses and viruses with large double-stranded genomes is considered in the context of the theory of symbiogenesis. BioMed Central 2008-09-18 /pmc/articles/PMC2567993/ /pubmed/18801176 http://dx.doi.org/10.1186/1471-2148-8-253 Text en Copyright ©2008 Bigot et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bigot, Yves Samain, Sylvie Augé-Gouillou, Corinne Federici, Brian A Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
title | Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
title_full | Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
title_fullStr | Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
title_full_unstemmed | Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
title_short | Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
title_sort | molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567993/ https://www.ncbi.nlm.nih.gov/pubmed/18801176 http://dx.doi.org/10.1186/1471-2148-8-253 |
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