Cargando…
Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study
Background. Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associat...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568004/ https://www.ncbi.nlm.nih.gov/pubmed/18556747 http://dx.doi.org/10.1093/ndt/gfn322 |
_version_ | 1782160027376680960 |
---|---|
author | Vychytil, Andreas Remón, César Michel, Catherine Williams, Paul Rodríguez-Carmona, Ana Marrón, Belén Vonesh, Ed van der Heyden, Synke Filho, Jose C. Divino |
author_facet | Vychytil, Andreas Remón, César Michel, Catherine Williams, Paul Rodríguez-Carmona, Ana Marrón, Belén Vonesh, Ed van der Heyden, Synke Filho, Jose C. Divino |
author_sort | Vychytil, Andreas |
collection | PubMed |
description | Background. Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associated with icodextrin have been reported. Methods. The primary objective of this multicentre, longitudinal, observational, non-interventional, prospective cohort study, which included 722 PD patients, was to evaluate the incidence of overall peritonitis in patients treated with icodextrin-containing PD solutions (Extraneal™) used during one long-dwell exchange/day compared with those treated with non-icodextrin-containing PD solutions. The secondary objective was to determine if culture-negative peritonitis rates differed between patients treated with icodextrin from two independent manufacturers. All peritonitis episodes were assessed by a Steering Committee in a blind manner. Results. There was no significant difference between icodextrin-treated and control patients in the adjusted overall, culture-positive or culture-negative peritonitis rates. When stratified by the icodextrin supplier, there was no significant difference in the adjusted rate of culture-negative peritonitis episodes between groups. Conclusion. Subjects receiving icodextrin as part of their PD regimen experienced neither a higher rate of culture-negative peritonitis nor a lower rate of infectious peritonitis compared with non-icodextrin users. There was no significant influence of the icodextrin raw material supplier on peritonitis rates. |
format | Text |
id | pubmed-2568004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25680042009-02-25 Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study Vychytil, Andreas Remón, César Michel, Catherine Williams, Paul Rodríguez-Carmona, Ana Marrón, Belén Vonesh, Ed van der Heyden, Synke Filho, Jose C. Divino Nephrol Dial Transplant Dialysis Background. Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associated with icodextrin have been reported. Methods. The primary objective of this multicentre, longitudinal, observational, non-interventional, prospective cohort study, which included 722 PD patients, was to evaluate the incidence of overall peritonitis in patients treated with icodextrin-containing PD solutions (Extraneal™) used during one long-dwell exchange/day compared with those treated with non-icodextrin-containing PD solutions. The secondary objective was to determine if culture-negative peritonitis rates differed between patients treated with icodextrin from two independent manufacturers. All peritonitis episodes were assessed by a Steering Committee in a blind manner. Results. There was no significant difference between icodextrin-treated and control patients in the adjusted overall, culture-positive or culture-negative peritonitis rates. When stratified by the icodextrin supplier, there was no significant difference in the adjusted rate of culture-negative peritonitis episodes between groups. Conclusion. Subjects receiving icodextrin as part of their PD regimen experienced neither a higher rate of culture-negative peritonitis nor a lower rate of infectious peritonitis compared with non-icodextrin users. There was no significant influence of the icodextrin raw material supplier on peritonitis rates. Oxford University Press 2008-11 2008-06-13 /pmc/articles/PMC2568004/ /pubmed/18556747 http://dx.doi.org/10.1093/ndt/gfn322 Text en © The Author [2008]. http://creativecommons.org/licenses/by-nc/2.0/uk/ The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org |
spellingShingle | Dialysis Vychytil, Andreas Remón, César Michel, Catherine Williams, Paul Rodríguez-Carmona, Ana Marrón, Belén Vonesh, Ed van der Heyden, Synke Filho, Jose C. Divino Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
title | Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
title_full | Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
title_fullStr | Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
title_full_unstemmed | Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
title_short | Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
title_sort | icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study |
topic | Dialysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568004/ https://www.ncbi.nlm.nih.gov/pubmed/18556747 http://dx.doi.org/10.1093/ndt/gfn322 |
work_keys_str_mv | AT vychytilandreas icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT remoncesar icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT michelcatherine icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT williamspaul icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT rodriguezcarmonaana icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT marronbelen icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT voneshed icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT vanderheydensynke icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT filhojosecdivino icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy AT icodextrindoesnotimpactinfectiousandculturenegativeperitonitisratesinperitonealdialysispatientsa2yearmulticentrecomparativeprospectivecohortstudy |