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Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing

Neuronal activity has an impact on β cleavage of amyloid precursor protein (APP) by BACE1 to generate amyloid-β peptide (Aβ). However, the molecular mechanisms underlying this effect remain to be elucidated. Cholesterol dependency of β cleavage prompted us to analyze immunoisolated APP-containing de...

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Detalles Bibliográficos
Autores principales:	Sakurai, Takashi, Kaneko, Kumi, Okuno, Misako, Wada, Koji, Kashiyama, Taku, Shimizu, Hideaki, Akagi, Takumi, Hashikawa, Tsutomu, Nukina, Nobuyuki
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568028/ https://www.ncbi.nlm.nih.gov/pubmed/18936252 http://dx.doi.org/10.1083/jcb.200804075

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