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Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice
BACKGROUND: Familial Alzheimer's disease-linked variants of presenilin (PSEN1 and PSEN2) contribute to the pathophysiology of disease by both gain-of-function and loss-of-function mechanisms. Deletions of PSEN1 and PSEN2 in the mouse forebrain result in a strong and progressive neurodegenerativ...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569036/ https://www.ncbi.nlm.nih.gov/pubmed/18834536 http://dx.doi.org/10.1186/1750-1326-3-14 |