Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice

Pre-existing immunity to human adenovirus serotype 5 (Ad5) is common in the general population. Bypassing pre-existing immunity could maximize Ad5 vaccine efficacy. Vaccination by the intramuscular (I.M.), nasal (I.N.) or oral (P.O.) route with Ad5 expressing Ebola Zaire glycoprotein (Ad5-ZGP) fully...

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Detalles Bibliográficos
Autores principales: Croyle, Maria A., Patel, Ami, Tran, Kaylie N., Gray, Michael, Zhang, Yi, Strong, James E., Feldmann, Heinz, Kobinger, Gary P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569416/
https://www.ncbi.nlm.nih.gov/pubmed/18958172
http://dx.doi.org/10.1371/journal.pone.0003548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569416/
https://www.ncbi.nlm.nih.gov/pubmed/18958172
http://dx.doi.org/10.1371/journal.pone.0003548

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