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A Novel Multiple Objective Optimization Framework for Constraining Conductance-Based Neuron Models by Experimental Data
We present a novel framework for automatically constraining parameters of compartmental models of neurons, given a large set of experimentally measured responses of these neurons. In experiments, intrinsic noise gives rise to a large variability (e.g., in firing pattern) in the voltage responses to...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Research Foundation
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570085/ https://www.ncbi.nlm.nih.gov/pubmed/18982116 http://dx.doi.org/10.3389/neuro.01.1.1.001.2007 |