Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

OBJECTIVE— Fatty acid–induced mitochondrial uncoupling and oxidative stress have been proposed to reduce cardiac efficiency and contribute to cardiac dysfunction in type 2 diabetes. We hypothesized that mitochondrial uncoupling may also contribute to reduced cardiac efficiency and contractile dysfun...

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Detalles Bibliográficos
Autores principales: Bugger, Heiko, Boudina, Sihem, Hu, Xiao Xuan, Tuinei, Joseph, Zaha, Vlad G., Theobald, Heather A., Yun, Ui Jeong, McQueen, Alfred P., Wayment, Benjamin, Litwin, Sheldon E., Abel, E. Dale
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570388/
https://www.ncbi.nlm.nih.gov/pubmed/18678617
http://dx.doi.org/10.2337/db08-0079

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