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Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice

OBJECTIVE—We determined whether muscle AMP-activated protein kinase (AMPK) has a role in the development of insulin resistance. RESEARCH DESIGN AND METHODS—Muscle-specific transgenic mice expressing an inactive form of the AMPK α2 catalytic subunit (α2i TG) and their wild-type littermates were fed e...

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Detalles Bibliográficos
Autores principales:	Fujii, Nobuharu, Ho, Richard C., Manabe, Yasuko, Jessen, Niels, Toyoda, Taro, Holland, William L., Summers, Scott A., Hirshman, Michael F., Goodyear, Laurie J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570392/ https://www.ncbi.nlm.nih.gov/pubmed/18728234 http://dx.doi.org/10.2337/db07-1187

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