Cargando…

Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to effectively reverse autoimmune diabetes. RESULTS—Anti-CD22/cal monoclonal antibody (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fiorina, Paolo, Vergani, Andrea, Dada, Shirine, Jurewicz, Mollie, Wong, Masie, Law, Kenneth, Wu, Erxi, Tian, Ze, Abdi, Reza, Guleria, Indira, Rodig, Scott, Dunussi-Joannopoulos, Kyri, Bluestone, Jeffrey, Sayegh, Mohamed H.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570398/ https://www.ncbi.nlm.nih.gov/pubmed/18689692 http://dx.doi.org/10.2337/db08-0420

Ejemplares similares

Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses
por: Carvello, Michele, et al.
Publicado: (2012)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes
por: Jurewicz, Mollie, et al.
Publicado: (2010)

The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes
por: Azzi, Jamil, et al.
Publicado: (2012)

B Cell Depletion Reduces the Number of Autoreactive T Helper Cells and Prevents Glucose-6-Phosphate Isomerase-Induced Arthritis
por: Frey, Oliver, et al.
Publicado: (2011)

Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens
por: Kleffel, Sonja, et al.
Publicado: (2015)

Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse
por: Shapiro, Roman M., et al.
Publicado: (2023)

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
por: Petrelli, Alessandra, et al.
Publicado: (2011)

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response
por: Kozakiewicz, Lee, et al.
Publicado: (2013)

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
por: Liang, Spencer C., et al.
Publicado: (2006)

Preformed Donor-specific Antibodies Against HLA Class II and Graft Outcomes in Deceased-donor Kidney Transplantation
por: Uffing, Audrey, et al.
Publicado: (2019)

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
por: Putnam, Amy L., et al.
Publicado: (2009)

A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes
por: Herold, Kevan C., et al.
Publicado: (2005)

PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant
por: Zheng, Peilin, et al.
Publicado: (2013)

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function
por: Long, S. Alice, et al.
Publicado: (2012)

Capture and enrichment of CD34-positive haematopoietic stem and progenitor cells from blood circulation using P-selectin in an implantable device
por: Wojciechowski, Joel C, et al.
Publicado: (2008)

Conversion to sirolimus for chronic renal allograft dysfunction: risk factors for graft loss and severe side effects
por: Abramowicz, Daniel, et al.
Publicado: (2008)

Risk factors for polyoma virus nephropathy
por: Prince, Olivier, et al.
Publicado: (2009)

Benefit of kidney transplantation beyond 70 years of age
por: Heldal, Kristian, et al.
Publicado: (2010)

Pancreas transplantation: differences in activity between Europe and the United States
por: Manuel González-Posada, José, et al.
Publicado: (2009)

Improvement in kidney transplantation in the Balkans after the Istanbul Declaration: where do we stand today?
por: Spasovski, Goce, et al.
Publicado: (2016)

Reciprocating living kidney donor generosity: tax credits, health insurance and an outcomes registry
por: Joshi, Shivam, et al.
Publicado: (2016)

A comparative study of reduced dose alemtuzumab in matched unrelated donor and related donor reduced intensity transplants
por: Jardine, Laura, et al.
Publicado: (2015)

Chronic Renal Transplant Rejection and Possible Anti-Proliferative Drug Targets
por: Bhatti, Adnan Bashir, et al.
Publicado: (2015)

Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease
por: Vickers, Mark A, et al.
Publicado: (2014)

BK polyoma virus infection and renal disease in non-renal solid organ transplantation
por: Kuppachi, Sarat, et al.
Publicado: (2016)

Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure
por: Hougardy, Jean-Michel, et al.
Publicado: (2016)

Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning
por: Townsend, William M, et al.
Publicado: (2013)

Identification of a Patient Population Previously Not Considered for Organ Donation
por: Barrois, Brad
Publicado: (2016)

Liver Transplantation after Exertional Heatstroke-Induced Acute Liver Failure
por: Inayat, Faisal, et al.
Publicado: (2016)

An Unusual Presentation of Nocardiosis in an Allogeneic Transplant Recipient
por: Ibrahim, Uroosa, et al.
Publicado: (2016)

Outcomes of living kidney donors with medullary sponge kidney
por: Cheungpasitporn, Wisit, et al.
Publicado: (2016)

An observational study of health literacy and medication adherence in adult kidney transplant recipients
por: Demian, Maryam N., et al.
Publicado: (2016)

Facilitating access to the renal transplant waiting list does not increase the number of transplantations: comparative study of two French regions
por: Lefort, Mathilde, et al.
Publicado: (2016)

Early Results of Pilot Study Using Hepatitis C Virus (HCV) Positive Kidneys to Transplant HCV Infected Patients with End-Stage Renal Disease Allowing for Successful Interferon-Free Direct Acting Antiviral Therapy after Transplantation
por: Gallegos-Orozco, Juan F, et al.
Publicado: (2016)

Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation in the United States Characterized by Kidney Donor Profile Index
por: Rege, Aparna, et al.
Publicado: (2016)

Hypercalcaemia preceding diagnosis of Pneumocystis jirovecii pneumonia in renal transplant recipients
por: Ling, Jonathan, et al.
Publicado: (2017)

Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
por: Katalinić, Nataša, et al.
Publicado: (2017)

Perioperative Plasma-Lyte use reduces the incidence of renal replacement therapy and hyperkalaemia following renal transplantation when compared with 0.9% saline: a retrospective cohort study
por: Adwaney, Anamika, et al.
Publicado: (2017)

First UK case report of kidney transplantation from an HIV-infected deceased donor to two HIV-infected recipients
por: Nolan, Eileen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ka0utn0j15tm3pbfsffe60hceq