Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

OBJECTIVE—To define the mechanisms underlying the accumulation of monocytes/macrophages in the islets of Langerhans. RESEARCH DESIGN AND METHODS—We tested the hypothesis that macrophage accumulation into the islets is caused by overexpression of the chemokine CCL2. To test this hypothesis, we genera...

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Detalles Bibliográficos
Autores principales: Martin, Andrea P., Rankin, Sara, Pitchford, Simon, Charo, Israel F., Furtado, Glaucia C., Lira, Sergio A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570399/
https://www.ncbi.nlm.nih.gov/pubmed/18633103
http://dx.doi.org/10.2337/db08-0625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570399/
https://www.ncbi.nlm.nih.gov/pubmed/18633103
http://dx.doi.org/10.2337/db08-0625

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