Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

OBJECTIVE—Cytokines contribute to β-cell destruction in type 1 diabetes. Endoplasmic reticulum (ER) stress–mediated apoptosis has been proposed as a mechanism for β-cell death. We tested whether ER stress was necessary for cytokine-induced β-cell death and also whether ER stress gene activation was...

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Detalles Bibliográficos
Autores principales: Åkerfeldt, Mia C., Howes, Jennifer, Chan, Jeng Yie, Stevens, Veronica A., Boubenna, Nacer, McGuire, Helen M., King, Cecile, Biden, Trevor J., Laybutt, D. Ross
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570400/
https://www.ncbi.nlm.nih.gov/pubmed/18591394
http://dx.doi.org/10.2337/db07-1802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570400/
https://www.ncbi.nlm.nih.gov/pubmed/18591394
http://dx.doi.org/10.2337/db07-1802

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