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Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

OBJECTIVE—Cytokines contribute to β-cell destruction in type 1 diabetes. Endoplasmic reticulum (ER) stress–mediated apoptosis has been proposed as a mechanism for β-cell death. We tested whether ER stress was necessary for cytokine-induced β-cell death and also whether ER stress gene activation was...

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Detalles Bibliográficos
Autores principales:	Åkerfeldt, Mia C., Howes, Jennifer, Chan, Jeng Yie, Stevens, Veronica A., Boubenna, Nacer, McGuire, Helen M., King, Cecile, Biden, Trevor J., Laybutt, D. Ross
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570400/ https://www.ncbi.nlm.nih.gov/pubmed/18591394 http://dx.doi.org/10.2337/db07-1802

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