Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

OBJECTIVE—Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, we sought to study the association of GCKR variants with metaboli...

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Detalles Bibliográficos
Autores principales: Orho-Melander, Marju, Melander, Olle, Guiducci, Candace, Perez-Martinez, Pablo, Corella, Dolores, Roos, Charlotta, Tewhey, Ryan, Rieder, Mark J., Hall, Jennifer, Abecasis, Goncalo, Tai, E. Shyong, Welch, Cullan, Arnett, Donna K., Lyssenko, Valeriya, Lindholm, Eero, Saxena, Richa, de Bakker, Paul I.W., Burtt, Noel, Voight, Benjamin F., Hirschhorn, Joel N., Tucker, Katherine L., Hedner, Thomas, Tuomi, Tiinamaija, Isomaa, Bo, Eriksson, Karl-Fredrik, Taskinen, Marja-Riitta, Wahlstrand, Björn, Hughes, Thomas E., Parnell, Laurence D., Lai, Chao-Qiang, Berglund, Göran, Peltonen, Leena, Vartiainen, Erkki, Jousilahti, Pekka, Havulinna, Aki S., Salomaa, Veikko, Nilsson, Peter, Groop, Leif, Altshuler, David, Ordovas, Jose M., Kathiresan, Sekar
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570409/
https://www.ncbi.nlm.nih.gov/pubmed/18678614
http://dx.doi.org/10.2337/db08-0516

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