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Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Potential for Rapid Screening

OBJECTIVE—People with the HLA genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (DR3/4-DQ8) are at the highest risk of developing type 1 diabetes. We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs). RESEARCH D...

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Detalles Bibliográficos
Autores principales:	Barker, Jennifer M., Triolo, Taylor M., Aly, Theresa A., Baschal, Erin E., Babu, Sunanda R., Kretowski, Adam, Rewers, Marian J., Eisenbarth, George S.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570414/ https://www.ncbi.nlm.nih.gov/pubmed/18694972 http://dx.doi.org/10.2337/db08-0605

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