Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants: A Lesson for Replication Studies

OBJECTIVE—Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A were originally shown to be associated with predisposition for type 2 diabetes in Finnish, Ashkenazi, and, more recently, Scandinavian populations, but they generated conflicting results in additional populations. We...

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Detalles Bibliográficos
Autores principales: Barroso, Inês, Luan, Jian’an, Wheeler, Eleanor, Whittaker, Pamela, Wasson, Jon, Zeggini, Eleftheria, Weedon, Michael N., Hunt, Sarah, Venkatesh, Ranganath, Frayling, Timothy M., Delgado, Marcos, Neuman, Rosalind J., Zhao, Jinghua, Sherva, Richard, Glaser, Benjamin, Walker, Mark, Hitman, Graham, McCarthy, Mark I., Hattersley, Andrew T., Permutt, M. Alan, Wareham, Nicholas J., Deloukas, Panagiotis
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570416/
https://www.ncbi.nlm.nih.gov/pubmed/18728231
http://dx.doi.org/10.2337/db08-0719

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