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Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation. Reprogramming entails multiple transgene integrations and occurs apparently stochastically in rare cells over many days. Tissue stem cells may be subject to less-stringent epigenetic restrictions than othe...

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Detalles Bibliográficos
Autores principales:	Silva, Jose, Barrandon, Ornella, Nichols, Jennifer, Kawaguchi, Jitsutaro, Theunissen, Thorold W, Smith, Austin
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570424/ https://www.ncbi.nlm.nih.gov/pubmed/18942890 http://dx.doi.org/10.1371/journal.pbio.0060253

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