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Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins from the membrane and also mediate the secretion of amyloid-β protein (Aβ) ha...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570425/ https://www.ncbi.nlm.nih.gov/pubmed/18942891 http://dx.doi.org/10.1371/journal.pbio.0060257 |