Cargando…

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins from the membrane and also mediate the secretion of amyloid-β protein (Aβ) ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hemming, Matthew L, Elias, Joshua E, Gygi, Steven P, Selkoe, Dennis J
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570425/ https://www.ncbi.nlm.nih.gov/pubmed/18942891 http://dx.doi.org/10.1371/journal.pbio.0060257

Ejemplares similares

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
por: Hemming, Matthew L., et al.
Publicado: (2009)

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates
por: Chen, Allen C., et al.
Publicado: (2010)

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
por: Funamoto, Satoru, et al.
Publicado: (2013)

Mechanisms of γ-Secretase Activation and Substrate Processing
por: Bhattarai, Apurba, et al.
Publicado: (2020)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
por: Jung, Joo In, et al.
Publicado: (2014)

Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
por: Liu, Xinyue, et al.
Publicado: (2020)

The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex
por: Orzeł, Urszula, et al.
Publicado: (2021)

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
por: Acx, Hermien, et al.
Publicado: (2017)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP
por: Petit, Dieter, et al.
Publicado: (2022)

Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase
por: Lichtenthaler, Stefan
Publicado: (2013)

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing
por: Stanga, Serena, et al.
Publicado: (2017)

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons
por: Watanabe, Hirotaka, et al.
Publicado: (2021)

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
por: Kedia, Shekhar, et al.
Publicado: (2021)

Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach
por: Pauli, Theresa M., et al.
Publicado: (2023)

Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis
por: Holmes, Oliver, et al.
Publicado: (2014)

Modulation of γ-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease
por: Svedružić, Željko M., et al.
Publicado: (2012)

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
por: Werner, Nadine T., et al.
Publicado: (2023)

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site
por: Chen, Shu-Yu, et al.
Publicado: (2023)

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells
por: Houser, Mei C. Q., et al.
Publicado: (2021)

Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain
por: Castro, Manuel A., et al.
Publicado: (2022)

GS-SMD server for steered molecular dynamics of peptide substrates in the active site of the γ-secretase complex
por: Orzeł, Urszula, et al.
Publicado: (2023)

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis
por: Chen, Allen C., et al.
Publicado: (2015)

Defining the minimum substrate and charge recognition model of gamma-secretase
por: Yan, Yan, et al.
Publicado: (2017)

Role of cholesterol in substrate recognition by [Formula: see text] -secretase
por: Nierzwicki, Łukasz, et al.
Publicado: (2021)

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
por: Ho, Michael, et al.
Publicado: (2010)

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
por: Liu, Lei, et al.
Publicado: (2019)

APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release
por: Koch, Matthias, et al.
Publicado: (2023)

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
por: Nyborg, Andrew C, et al.
Publicado: (2006)

Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation
por: Trambauer, Johannes, et al.
Publicado: (2019)

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides
por: Liu, Lei, et al.
Publicado: (2021)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

Gene Expression Profiling in Cells with Enhanced γ-Secretase Activity
por: Magold, Alexandra I., et al.
Publicado: (2009)

The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer’s Disease
por: Svedružić, Željko M., et al.
Publicado: (2023)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP
por: Weissmiller, April M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_481gsjr7fdvatjoi84d64cjc3i